Karanga, in the 17th minute, opened the scoring, which was later increased by Luís Tati, in the 64th minute.
With this victory, Sagrada Esperança is closer to winning the second title of Girabola, in dispute with Petro de Luanda, which has one point less and 15 titles won.
The two teams can decide the title in the last round, at the 11 de Novembro Stadium, in Luanda.
On Friday, the Angolan Football Federation made official the withholding of all points to Ferrovia do Huambo in the Angolan soccer championship, for forgery of documents of footballer Alberto Xavier 'Vingumba'.
Ferrovia, which has already promised to appeal to FIFA against the sanction imposed by the federative body, was also relegated and suspended for a year.
With the withdrawal of the points, the league table changed, although this did not affect the top of the standings.