Organised by the Corporate Council on Africa in partnership with the Angolan government, the summit will run until Friday under the theme "Sustainable Partnerships for Growth", focusing on areas such as infrastructure, energy, agriculture, technology and regional value chains.
Delegations from over 40 African countries are expected, as well as representatives from US financial agencies such as the Exim Bank and the US International Development Finance Corporation (DFC) and several dozen companies from the United States.
The agenda includes thematic panels, bilateral meetings and business promotion sessions, and new memoranda of understanding and investments in priority sectors are also expected to be announced.
The meeting comes in a context of growing international competition for markets and resources in Africa, with Angola trying to position itself as a platform for investment entry, supported by projects such as the Lobito Corridor.
It also comes at a critical time in relations between Washington and the African continent, after US President Donald Trump promoted a series of cuts in financial support that affect many African countries and other hostile measures in mobility and trade.