Tady, Femi and Chico scored the goals of Sagrada Esperança, while Das Faa reduced to the 'police' in the capital.
In a game that took place at Dundo stadium, in Lunda Norte province, the host team took the best and continues to advantage for the second leg game, scheduled for Luanda, on 28 March.
Interclube has won the Angola Cup three times (1986, 2003 and 2001), while Sagrada Esperança has won a trophy in 1999.
Also this Wednesday, for the same competition, 1º de Agosto, holder of the title, will play against Bravos do Maquis, at the 11 de Novembro stadium, in Luanda.
The Angola Cup is the second largest football competition in the country after Girabola.